Research Senior Associate who designs, executes and manages research projects investigating the neurodegenerative disease glaucoma and other eye disease in a foundational (basic) biological/health science research laboratory in the Department of Ophthalmology and Visual Sciences; collaborates with principal investigator (PI) to develop and implement goals and objectives of studies; conceptualizes, designs and executes complex laboratory experiments; plans and executes advanced molecular, cellular and physiological techniques; plans, coordinates and oversees processing and analysis of data; analyzes and interprets research data; develops and implements new and/or revised research methodology and techniques; plans and tests experimental designs, sampling techniques, and analytical methods; develops and establishes research controls, criteria and standards; performs critical analysis of literature relevant to research; collaborates with principal investigator to write and prepare research papers and manuscripts for publication and presentation at national and conferences and workshops, and in the writing of project reports, articles and other documents; attends and presents research results at national and international scientific conferences, workshops and seminars; assists with development, writing and preparation of grant proposals to obtain new or renewal of extramural funding in support of research; investigates, identifies and recommends possible sources of research funding; participates in developing and managing grant budgets; monitors expenses; monitors and enforces laboratory safety procedures to ensure compliance with OSHA regulations, as well as local, state and federal regulations, including proper disposal and maintenance of regulated materials; trains and/or supervises research staff; manages daily operations of the laboratory; oversees and initiates procurement of lab supplies and equipment; provides technical assistance and supervision of equipment; negotiates and oversees equipment service contracts and repairs.

Minimum Education Required

Masters Level Degree or equivalent combination of education and experience.

Required Qualifications

A Masters degree in an appropriate biological/health science or an equivalent combination of education and experience is required. 3-5 years of relevant experience. Considerable experience in a biological/health research capacity is required. A Doctoral degree in an appropriate biological/health science field is desirable. Requires successful completion of a background check; qualified candidates may be asked to complete a pre-employment physical, including a drug screen.

Function: Research and Scholarship

Sub Function: Research

Career Band: S

Career Level: S2

We are seeking a Researcher interested in ocular biology to join the laboratory of Dr. Krish Kizhatil in the Department of Ophthalmology and Visual Sciences at The Ohio State University. We study glaucoma, a common ocular disease involving harmfully high intraocular pressure (IOP; pressure inside eye) and neural degeneration in the optic nerve and retina. Our goal is to find cures for glaucoma. Our strong interests include finding the molecules and mechanisms controlling normal intraocular pressure, the impact of age on these mechanisms. This includes molecular mechanisms controlling developmental and adult biology of structures controlling IOP the Schlemms canal and trabecular meshwork including mechanism by which neural control of IOP is accomplished including mechanotransduction and other cellular signaling pathways. In addition, new research will be initiated into finding resiliency factor to prevent neurodegeneration of the retinal ganglion cells. We are also interested in the role of transcription factors and other mutations in both ocular development and adult disease. We use an array of mouse models, genetic, viral, and physiologic approaches. The Kizhatil lab has also established collaborators at Columbian University, Duke University and Imperial College of London who are leaders in the field. We eventually hope to collaborate with physicians to translate our finding to the clinic.

Applicants with a PhD and relevant postdoctoral experience will be preferred. The successful candidate will make critical research contributions both intellectually and experimentally, with a major focus on either ocular fluid drainage biology, ocular development/ developmental glaucoma, or mechanisms of neurodegeneration. The applicant must be and independent individual who is enthusiastic and curious with proven, strong research, organizational and managerial skills. Willingness to learn new science is a requirement. Strong communication and writing skills are a must. Preference will be given to applicants with prior research experience with:

• Mouse models and genetics
• Confocal and electron microscopy
• Cutting edge genomics including single cell sequencing, ATAC-seq.
• Proteomics
• Viral Vectors

The incumbent will be expected to help establish the lab and regularly train junior personnel and be a mentor. The position is well-suited for a productive and dedicated individual who can contribute at a high level but wants to spend more time at the bench. This position is available immediately.

At The Ohio State University, through reflection, evaluation and meaningful action, we aim to reinforce our ethical culture and live shared values to advance our core work of teaching, learning, research and service. Our shared values are: Excellence and Impact, Diversity and Innovation, Inclusion and Equity, Care and Compassion and Integrity and Respect.